ABSTRACT
Coronavirus disease 2019 (COVID-19) can cause damage to multiple organ, not only to the lungs, but also to the kidneys. Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) can cause acute and chronic kidney disease through direct viral infection, indirect injury, and vaccination-related injury. Like lung injury, kidney injury is also an important aspect affecting the severity and prognosis of SARS-CoV-2. This article summarizes the pathogenesis, pathological manifestations, and clinical features of SARS-CoV-2 direct or indirect renal injury. Including direct injury, indirect injury, special comorbidities (receiving kidney transplantation and CKD), and vaccine-related renal injury, and exploring the possible therapeutic effect of anti-SARS-CoV-2 therapy on renal injury. The purpose is to provide reference for understanding COVID-19-related renal injury, guiding clinical and pathological diagnosis and treatment, and evaluating prognosis. This article is protected by copyright. All rights reserved.
ABSTRACT
Since the outbreak of the Ukrainian-Russian conflict on 24 February 2022, Ukraine’s economy, society, and cities have been devastated and struck on multiple fronts, with large numbers of refugees fleeing to neighboring countries. The lighting systems in Ukrainian cities have been severely restricted due to Russian missile bombing and curfew policies. The power shortages adversely affected the livelihoods of the Ukrainian residents dramatically. For a timely assessment of the power shortages’ extent and the affected population in Ukraine, this study tracked the dynamics of nighttime light emissions in Ukraine based on the newly developed daily Black Marble product (VNP46A2) from NASA. The results show that the average light radiance in Ukrainian urban areas has decreased by about 37% since the eruption of the war, with Kiev city being the most dramatic region, having a post-conflict decrease of about 51%. In addition, by introducing near-real-time population data, we have implemented a survey of the affected population in Ukraine suffering from war-induced power shortages. Estimates show that about 17.3 million Ukrainian residents were affected by power shortages. In more detail, the number of children under 10 years old was about 2.35 million (about 5.24% of the total population), while the number of elderly people over 60 years old was about 3.53 million (about 7.86% of the total population). Generally, the results of this study could contribute positively to the timely assessment of the impact of the conflict and the implementation of humanitarian relief.
ABSTRACT
Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as "podocyte disease." There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations. Primary podocytosis mostly manifests as nephrotic syndrome. At present, first-line treatment is based on glucocorticoid administration combined with immunosuppressive therapy, but some patients still progress to end-stage renal disease. In Asia, especially in China, traditional Chinese medicine (TCM) still plays an important role in the treatment of kidney diseases. This study summarizes the potential mechanism of TCM and its active components in protecting podocytes, such as repairing podocyte injury, inhibiting podocyte proliferation, reducing podocyte apoptosis and excretion, maintaining podocyte skeleton structure, and upregulating podocyte-related protein expression. At the same time, the clinical efficacy of TCM in the treatment of primary podocytosis (including idiopathic membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis) is summarized to support the development of new treatment strategies for primary podocytosis.